Endocrine Abstracts

Heterotrimeric G proteins mediate signalling from 7 transmembrane domain receptors to a variety of intracellular effectors. Regulators of G protein signalling (RGS) are a novel family of proteins, that act as GTPase activating proteins. In the human myometrium signalling via G proteins may be altered during pregnancy and labour, suggesting a physiological role of G proteins in human gestation. Our aim was to investigate the expression of RGS proteins in the human myometrium. E...

A 29-year-old lady with known autoimmune thyrotoxicosis (TPO 712 IU/ml) presented with an urticarial rash. She was on carbimazole. A diagnosis of drug-induced reaction was suspected and treated as such. Her carbimazole was discontinued. After a day of treatment with steroids and antihistamines, she experienced flushing, orthostatic hypotension and difficulty in breathing. She was treated for anaphylaxis with adrenaline on intensive care unit. A formal Dermatology opinion was p...